Sunday, July 31, 2011

'Super antibody' fights off flu

Swine flu virusA jab protecting against all flu viruses is considered a holy grails of vaccine research

The first antibody which can fight all types of the influenza A virus has been discovered, researchers claim.

Experiments on flu-infected mice, published in Science Express, showed the antibody could be used as an "emergency treatment".

It is hoped the development will lead to a "universal vaccine" - currently a new jab has to be made for each winter as viruses change.

Virologists described the finding as a "good step forward".

Many research groups around the world are trying to develop a universal vaccine. They need to attack something common to all influenza which does not change or mutate.

Human source

It has already been suggested that some people who had swine flu may develop 'super immunity' to other infections.

Scientists from the Medical Research Council's National Institute for Medical Research at Mill Hill and colleagues in Switzerland looked at more than 100,000 samples of immune cells from patients who had flu or a flu vaccine.

They isolated an antibody - called FI6 - which targeted a protein found on the surface of all influenza A viruses called haemagglutinin.

Sir John Skehel, MRC scientist at Mill Hill, said: "We've tried every subtype of influenza A and it interacts with them all.

"We eventually hope it can be used as a therapy by injecting the antibody to stop the infection."

Professor Antonio Lanzavecchia, director of the Institute for Research in Biomedicine, Switzerland, said: "As the first and only antibody which targets all known subtypes of the influenza A virus, FI6 represents an important new treatment option."

When mice were given FI6, the antibody was "fully protective" against a later lethal doses of H1N1 virus.

Mice injected with the antibody up to two days after being given a lethal dose of the virus recovered and survived.

This is only the antibody, however, not the vaccine.

A vaccine would need to trigger the human body's immune system to produce the antibody itself.

Sir John said the structure of the antibody and how it interacted with haemagglutinin had been worked out, which would help in the search for a vaccine, but that was "definitely years away".

Professor John Oxford, a virologist at Queen Mary, University of London, said: "It's pretty good if you've got one against the whole shebang, that's a good step forward."

Source: http://www.bbc.co.uk/go/rss/int/news/-/news/health-14324901

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Job: Building and Social Housing Foundation ? International Programme?

Source: http://www.globalhealthhub.org/2011/07/29/job-building-and-social-housing-foundation-international-programme/

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Greater Breast Density May Raise Cancer Risk

WEDNESDAY, July 27 (HealthDay News) -- Greater breast density is associated with an increased risk of breast cancer and certain aggressive tumor traits, new research says.

In the study, published in the July 27 online edition of the Journal of the National Cancer Institute, researchers used mammography to compare breast density in 1,042 postmenopausal women with breast cancer and a control group of 1,794 postmenopausal women without breast cancer.

Breast density on mammograms is determined by the proportions of fat, connective tissue and epithelial tissue in the breast. Previous research has shown that women with higher amounts of epithelial and stromal tissue have more density and higher risk of breast cancer. But it hasn't been clear whether breast density is associated with specific tumor characteristics and tumor type.

As expected, this new study found that breast cancer risk rose progressively with increasing breast density. The researchers also found that the link between density and breast cancer was stronger for larger tumors than for smaller tumors, for high-grade tumors compared to low-grade tumors, for estrogen receptor-negative tumors than for estrogen receptor-positive tumors, and for ductal carcinoma in situ (DCIS) tumors than for invasive tumors.

There was no association between breast density and other markers of tumor aggressiveness, including nodal involvement and HER2 status, the study authors noted in a journal news release.

"Our results suggest that breast density influences the risk of breast cancer subtypes by potentially different mechanisms," wrote Rulla M. Tamimi, of Harvard Medical School and Brigham and Women's Hospital in Boston, and colleagues.

"Further studies are warranted to explain underlying biological processes and elucidate the possible pathways from high breast density to the specific subtypes of breast carcinoma," the authors added.

-- Robert Preidt

MedicalNewsCopyright � 2011 HealthDay. All rights reserved.

SOURCE: Journal of the National Cancer Institute, news release, July 27, 2011


Source: http://www.medicinenet.com/guide.asp?s=rss&a=147505&k=Womens_Health_General

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Saturday, July 30, 2011

Report: Health Care Spending to Absorb a Fifth of GDP by 2020

By Haydn Bush July 29, 2011

A new report in Health Affairs projects that U.S. health care spending will grow to over $4.6 trillion by 2020.

A report this week in Health Affairs projects that overall U.S. health care spending will reach $4.638 trillion, or 19.8 percent of GDP, by 2020. From 2010-2020, the report estimates that health care spending will grow at an average of 5.8 percent per year.

In particular, the report projects a spike in health care spending of 8.3 percent in 2014, when key provisions of the Affordable Care Act are implemented and 22.9 million newly insured Americans begin using additional health care services.

Among the other findings:

  • National health care spending reached nearly $2.6 trillion in 2010, up 3.9 percent from 2009.
  • In 2010, spending in U.S. hospitals increased 4.6 percent to $794.3 billion.
  • In 2010, the health care share of U.S. GDP remained at 17.6 percent, roughly the same as 2009.
  • Medicare spending reached $525 billion in 2010. However, the overall growth rate slowed from 7.9 percent in 2009 to 4.5 percent in 2010, which the report attributed primarily to a 3.4 percent reduction in Medicare's payments to private health plans.

Click here to read the full report.

The opinions expressed by authors do not necessarily reflect the policy of Health Forum Inc. or the American Hospital Association.

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Source: http://www.hhnmag.com/hhnmag/HHNDaily/HHNDailyDisplay.dhtml?id=1800004419

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Health Tip: When Sleep Apnea Affects Children

Source: http://www.medicinenet.com/guide.asp?s=rss&k=DailyHealth&a=147556

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Mammography Technology Ineffective in Finding Breast Cancer

Source: http://www.medicaldaily.com/news/20110729/6985/cad-technology-ineffective-finding-breast-tumors-cancer.htm

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Clot risk increase with sudden drop in blood pressure during dialysis

Source: http://www.medicaldaily.com/news/20110730/6987/clots-risk-increase-with-low-blood-pressure-during-dialysis.htm

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